Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Signal initiation in biological systems: the properties and detection of transient extracellular protein interactions. Infertility in female mice with an oocyte-specific knockout of GPI-anchored proteins. Treatment of mouse oocytes with PI-PLC releases 70-kDa (p I 5) and 35- to 45-kDa (p I 5.5) protein clusters from the egg surface and inhibits sperm-oolemma binding and fusion. Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion. Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1. The gamete fusion process is defective in eggs of Cd9-deficient mice. Requirement of CD9 on the egg plasma membrane for fertilization. Severely reduced female fertility in CD9-deficient mice. Le Naour, F., Rubinstein, E., Jasmin, C., Prenant, M. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Fertilization: a sperm’s journey to and interaction with the oocyte. Mammalian membrane block to polyspermy: new insights into how mammalian eggs prevent fertilisation by multiple sperm. The cell biology of mammalian fertilization. Our discovery of an essential receptor pair at the nexus of conception provides opportunities for the rational development of new fertility treatments and contraceptives. Rapid shedding of Juno from the oolemma after fertilization suggests a mechanism for the membrane block to polyspermy, ensuring eggs normally fuse with just a single sperm. Female mice lacking Juno are infertile and Juno-deficient eggs do not fuse with normal sperm. We show that the Izumo1–Juno interaction is conserved within several mammalian species, including humans. Here we identify folate receptor 4 (Folr4) as the receptor for Izumo1 on the mouse egg, and propose to rename it Juno. Izumo1 is an essential sperm cell-surface protein, but its receptor on the egg has not been described. The molecular basis of sperm–egg recognition is unknown, but is likely to require interactions between receptor proteins displayed on their surface.
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They are lifetime members of The Episcopal Church of the Advent and also attend Episcopal Church of the Ascension in Carrabelle.Fertilization occurs when sperm and egg recognize each other and fuse to form a new, genetically distinct organism. June is married to Jack Richardson and they are parents of three grown sons, Wilson, Michael and James Richardson. Yes, she is an avid Gator Fan, however supports many activities at FSU including Opening Nights and attends many events at the Donald Tucker Center.
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June is a graduate of Leon High School and The University of Florida where she earned a Bachelor of Science Degree in Business. Women’s Council of Realtors – 2017 VP of Membership Greater Tallahassee Chamber of Commerce and Leads Group 6 Leadership Tallahassee - Charter Member - Class I Her background and expertise in sales and marketing along with her love for the area make her a natural for the Real Estate Profession.Īlways active in the community, memberships include:
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She loves looking for homes for a living. She has sold 44 homes in her first 3 years, representing both buyers and sellers. She has managed property and was Commercial Development Property Manager for Comcast. In her lifetime, she has personally bought 5 homes and sold 4 homes. June knows Tallahassee and is also a part-time resident in Carrabelle. in 2017 June and Peggy Dye opened Dye & Wright Realty, LLC Their mission is connect the WRIGHT Buyers with the WRIGHT sellers to find the WRIGHT Homes AND do things the WRIGHT WAY! In 2014, she finally decided to pursue her dream sales career in Real Estate. June Wright was raised in Tallahassee and worked as a Sales Consultant and Sales Manager for Sara Lee Corporation, the Tallahassee Democrat and Comcast.